Abstract
Verbascoside is a natural antioxidant extracted from Pedicularis striata Pall (Jueyehesen). After being treated with 20 µmol/l verbascoside, the growth curve
and mitotic index of human gastric adenocarcinoma MGc80-3 cells decreased remarkably,
cell doubling time was delayed, the cellular growth inhibitory rate amounted to 53.2%,
cell surface charge assayed by cell electrophoresis obviously changed, the electrophoresis
rate dropped from 3.51 µm/s/v/cm to 2.74, i.e., the percent of retardation reached
28.4%. There was a 75% decrease of the tumorigenicity for the treated cells compared
with the untreated cells inoculated subcutaneously in BALB/C nude mice. Scanning electron
microscopy revealed that the microvilli on the surface of treated cells had been reduced
obviously. It confirmed that verbascoside, similar to DMSO, could reverse MGc80-3
cells' malignant phenotypic characteristics and induced redifferentiation of MGc80-3
cells.
Key words
Verbascoside -
Pedicularis striata
- Scrophulariaceae - antioxidant - human gastric adenocarcinoma MGc80-3 - redifferentiation
